BackgroundHIV cure research involving cell and gene therapy has intensified in recent years. There is a growing need to identify ethical standards and safeguards to ensure cell and gene therapy (CGT) HIV cure research remains valued and acceptable to as many stakeholders as possible as it advances on a global scale.MethodsTo elicit preliminary ethical and practical considerations to guide CGT HIV cure research, we implemented a qualitative, in-depth interview study with three key stakeholder groups in the United States: (1) biomedical (...) HIV cure researchers, (2) bioethicists, and (3) community stakeholders. Interviews permitted evaluation of informants’ perspectives on how CGT HIV cure research should ethically occur, and were transcribed verbatim. We applied conventional content analysis focused on inductive reasoning to analyze the rich qualitative data and derive key ethical and practical considerations related to CGT towards an HIV cure.ResultsWe interviewed 13 biomedical researchers, 5 community members, and 1 bioethicist. Informants generated considerations related to: perceived benefits of CGT towards an HIV cure, perceived risks, considerations necessary to ensure an acceptable benefit/risk balance, CGT strategies considered unacceptable, additional ethical considerations, and considerations for first-in-human CGT HIV cure trials. Informants also proposed important safeguards to developing CGT approaches towards an HIV cure, such as the importance of mitigating off-target effects, mitigating risks associated with long-term duration of CGT interventions, and mitigating risks of immune overreactions.ConclusionOur study identified preliminary considerations for CGT-based HIV cure across three key stakeholder groups. Respondents identified an ideal cure strategy as one which would durably control HIV infection, protect the individual from re-acquisition, and eliminate transmission to others. Known and unknown risks should be anticipated and perceived as learning opportunities to preserve and honor the altruism of participants. Preclinical studies should support these considerations and be transparently reviewed by regulatory experts and peers prior to first-in-human studies. To protect the public trust in CGT HIV cure research, ethical and practical considerations should be periodically revisited and updated as the science continues to evolve. Additional ethics studies are required to expand stakeholder participation to include traditionally marginalized groups and clinical care providers. (shrink)

In ancient times, when persuasion played the role of public force, eloquence was necessary. Of what use would it be today, when public force has replaced persuasion. One needs neither art nor metaphor to say such is my pleasure. Jean Jacques Rousseau.

Rooting, defined as a spectator’s demonstrative encouragement of a contestant’s effort, ideally has the morally positive aspects of benevolent concern and helpfulness but in practice strains against reasonable standards of conduct by being rude, excessively biased, exploitative, fanatical, and superstitious. Rooting may activate an atavistic, morally cogent sense of fighting for one’s group that is at odds with the universalism of civilized morality. The ‘merely play’ excuse can cut both ways, deflecting moral objections but also removing moral credit from rooting. (...) Although rooting is often not humane, humane rooting can occur and is supported by humane commentary by sports participants, broadcasters, and journalists. Humane rooting supports the premise of benevolence theories (Mengzi, Hutcheson) that morally ideal benevolence has a foothold in an innate general benevolence – seen in this area especially in benevolence toward efforts. Being partisan, excited, and demonstrative, rooters cannot perfectly embody ‘universal calm benevolence’, but they can consciously minimize the inhumane aspects of rooting and achieve a more fully prosocial satisfaction. (shrink)

In this book, Steven G. Smith focuses on the guidance function in language and scripture and evaluates the assumptions and ideals of scriptural religion in global perspective. He brings to language studies a new pragmatic emphasis on the shared modeling of life-in-the-world by communicators constantly depending on each other's guidance. Using concepts of axiality and axialization derived from Jaspers' description of the 'Axial Age', he shows the essential role of scripture in the historical progress of communicative action. This volume (...) clarifies the formative power of scriptures in religions of the 'world religion' type and brings scripture into philosophy of religion as a major cross-cultural category of study, thereby helping philosophy of religion find a needed cross-cultural footing. (shrink)

Past research has found that skin colouration, particularly facial redness, influences the perceived health and emotional state of target individuals. In the current work, we explore several extensions of this past research. In Experiment 1, we manipulated facial redness incrementally on neutral and angry faces and had participants rate each face for anger and health. Different red effects emerged, as perceived anger increased in a linear manner as facial redness increased. Health ratings instead showed a curvilinear trend, as both extreme (...) paleness and redness were rated as less healthy than moderate levels of red. Experiment 2 replicated and extended these findings by manipulating the masculinity of both angry and neutral faces that varied in redness. The results found the effect of red on perceived anger and health was moderated by masculine face structure. Collectively, these results show that facial redness has context dependent effects that vary based on facial expression, appearance, and differentially impact ratings of emotional states and health. (shrink)

An original metaphysical proposal building on classical and contemporary sources. In Centering and Extending, Steven G. Smith retrieves and refashions some of the best ideas of classical and early modern metaphysics to support insight into the natures of mental and material beings and their relations. Avoiding what he critiques as distortive paths of idealism, materialism, repressive monism, and overly permissive pluralism, Smith builds his framework on centering and extending as universal principles of formation. Identifying the basic consistency of being (...) with these principles in symmetrical partnership enables a naturalist process view that, unlike Whitehead’s, does not overbalance toward the subjective and teleological and, unlike Deleuze and Guattari’s, does not overbalance toward the material and chaotic. This view supports useful conceptions of mind and matter, form and energy, reason and cause, and a layered world order without relying on a blind concept of supervenience or emergence. It also respects and reinforces a division of roles between metaphysical sense-making and spiritual determinations of meaningfulness. Steven G. Smith is Jennie Carlisle Golding Professor of Philosophy at Millsaps College. He is the author of several books, including Worth Doing, also published by SUNY Press. (shrink)

A concept of merit is used for spiritual accounting in many religious traditions, seemingly a substantial point of connection between religion and ordinary morality. Teachings of “merit transfer” (as in Buddhism and Roman Catholicism) might make us doubt this connection since they violate the principle that merit must be earned. If we examine the structure of ordinary schemes of desert, however, we find that personal worth is posited for a variety of reasons; the basic requirement in this realm is not (...) earning by individuals but rather a community’s program for cultivating desirable collaboration among its members. There are strong enough parallels between religiously envisioned merit transfer and socially normal conferrals and sharings of worth that we can conclude that the religious posits of transferred merit are indeed comprehensible as merit, whatever other problems of comprehensibility they pose. (shrink)

To the French critics who originally labelled certain films noir it seemed that a class of Hollywood products had gone darker during the war years – as though a dark filter had been placed over the lens. Films were not designed or marketed as noir, and retrospectively noir's status as a genre is still unsettled. Yet there is widespread interest today in experiencing diverse films as noir, and even in using a Noir Filter in Instagram and video games. Pursuing the (...) filter clue, the noir experience can be thought of as subjection to a dark filtering of narrative. Image filtering styles can help to resolve not only the puzzle of noir's quasi-genre status but also an issue of general interest in aesthetic experience. The use of image filters makes a distinctively powerful contribution to the experience of a work or genre, or to the cultural dominance of an aesthetic regime, due to the unobtrusive formative role it plays in the economy of experience. (shrink)

Once upon a time, I attempted to create a web-based one-stop-shop for global poverty relief called the Maximin Project. Drawing on aspects of that experience, I show that although some existing ways of rating and recommending charities are significantly better than others, there remain certain challenges that need to be overcome. Specifically, I argue that the emerging Effective Altruism movement, with its emphasis on measurable effectiveness, runs the risk of neglecting a whole range of projects that are necessary for a (...) well-rounded approach to human development. I briefly model an alternative virtue-based approach that calls on the personal insight of individual researchers and practitioners in addition to the more directly experimental approach of organizations like GiveWell. (shrink)

If the mental is subject to indeterminacy, does this rule out the possibility of psychophysical laws? One might think so. However, Jaegwon Kim has argued for the existence of a kind of psychophysical law that is not obviously susceptible to problems posed by indeterminacy. I begin by introducing a weak and relatively uncontroversial indeterminacy thesis. Then, by appealing to constraints on theories of strong supervenience and to general considerations about the nature of indeterminacy, I argue that even Kim’s laws cannot (...) accommodate indeterminacy. The result is an argument against the possibility of Kim‐Style psychophysical laws. (shrink)

Some of kant's rationales for conceiving the highest good of morality as virtue rewarded with happiness rest on the subject's "necessary" natural desire for happiness, While others appeal to a still-Obscure principle of moral desert. The principle, I argue, Is that the moral agent qua moral necessarily hopes for the "approval" of fellow moral legislators and god, Who "would" (did they exist, And if they could) signify their approval by bestowing the means of happiness.

A fraughtness in the human communicative situation—the impossibility of assuring collegial equality in our presentations to each other, given that we are striving to control each other’s attention—is compellingly figured in the treatment of the focus plane of show entertainment in film musicals. In Busby Berkeley’s seminal work in 42nd Street (1933), the portrait of the Great Showman in The Great Ziegfeld (1936), and Brian De Palma’s satirical Phantom of the Paradise (1974) it may be seen that the show musical (...) genre has a distinctive preoccupation with the focus plane of performance and constructs this place of encounter as fraught—in the sense not only that characters are shown in possibly untenable positions but that viewers are made to recognize that they might be in an untenable relationship with the performers and makers of the shows they are looking at. (shrink)

"To my knowledge, there has never [before] been a volume that analyzes, in one place, the actual language of science--those elements of thinking that are acknowledged to be the basis of scientific thought. . . . [Thus] this is a very important book, contributing to several fields: science, education, rhetoric, medicine, and perhaps even philosophy. . . . Darian's erudition is truly astonishing." --Celest A. Martin, Associate Professor, College Writing Program, University of Rhode Island From astronomy to zoology, the practice (...) of science proceeds from scientific ways of thinking. These patterns of thought, such as defining and classifying, hypothesizing and experimenting, form the building blocks of all scientific endeavor. Understanding how they work is therefore an essential foundation for everyone involved in scientific study or teaching, from elementary school students to classroom teachers and professional scientists. In this book, Steven Darian examines the language of science in order to analyze the patterns of thinking that underlie scientific endeavor. He draws examples from university science textbooks in a variety of disciplines, since these offer a common, even canonical, language for scientific expression. Darian identifies and focuses in depth on nine patterns--defining, classifying, using figurative language, determining cause and effect, hypothesizing, experimenting, visualizing, quantifying, and comparing--and shows how they interact in practice. He also traces how these thought modes developed historically from Pythagoras through Newton. (shrink)

The history of economic thought has always attracted some of the brightest minds in the discipline. These chroniclers of development have helped form our current views, and it is no surprise that many among them have been at the forefront of new movements in the history of ideas. This notable collection summarizes the work of these key historians of economics and attempts to quantify their impact. Some of the writers covered, such as Friedrich Hayek and Joan Robinson, are already assured (...) of their place among the greatest economists of the twentieth century, but the collection also stresses the influence of those still active in shaping our perceptions - including Mark Blaug, Samuel Hollander and Donald Winch. Written by an impressive roster of contributors, many of whom are themselves well-known in the history of economic thought, this key book features writings from John Creedy, Roger Blackhouse and Neil De Marchi, as well as the editors of the collection as a whole, Warren J. Samuels and Steven Medema. (shrink)

Emotion expressions convey valuable information about others’ internal states and likely behaviours. Accurately identifying expressions is critical for social interactions, but so is perceiver confidence when decoding expressions. Even if a perceiver correctly labels an expression, uncertainty may impair appropriate behavioural responses and create uncomfortable interactions. Past research has found that perceivers report greater confidence when identifying emotions displayed by cultural ingroup members, an effect attributed to greater perceptual skill and familiarity with own-culture than other-culture faces. However, the current research (...) presents novel evidence for an ingroup advantage in emotion decoding confidence across arbitrary group boundaries that hold culture constant. In two experiments using different stimulus sets participants not only labeled minimal ingroup expressions more accurately, but did so with greater confidence. These results offer novel evidence that ingroup advantages in emotion decoding confidence stem partly from social-cognitive processes. (shrink)

ABSTRACT To understand the internal structure of moral positions and the nature of moral disagreements, it would be useful to have a “moral sense” model of our different types of moral sensitivity, from our relatively spontaneous friendliness to our appreciation for traditional community norms, ideal ethical norms, and spiritual appeals to ultimate concern. After the first round of modern moral sense theory in Shaftesbury, Hutcheson, and Edwards, most discussions of the moral sense concept have centered on general theses about moral (...) value (objective or subjective, rational or emotional) without attending to this complexity. Even though the familiar positions in these discussions are not reconcilable on the plane of ethical theory, they need not be seen as simply antagonistic. Working with clearly differentiated senses of both “moral” and “sense,” this article refashions “moral sense theory” as a way of placing the insights of the classic moral sense theories, ethical rationalism, and a distinctly spiritual sensibility in a conceptually stable and empirically more discriminating order. The article also suggests strengthening the realist premise of moral sensing by invoking the model of a game player’s operational sense of how things are going in pursuit of a game’s objectives. (shrink)

Word usage and behavior show that most people think of music as a distinct category of valuable experience, yet music lovers are known to have widely different ideas of what music offers. Some love its power to express or arouse emotions; some love the immediate sensuous-kinetic pleasure of tone and beat; some find a compelling sense of individual or communal identity in it; some are caught by the puzzle-solving interest of its compositional designs. Most will agree, nonetheless, that music is (...) wonderful in a musical way—an expresser of emotions not interchangeable with other expressive means, a source of pleasure not interchangeable with other sources, and so on—which seems to indicate that an essential musicality.. (shrink)

This study examines developments in Karl Barth's early theology (to 1932) and Emmanuel Levinas's philosophy (as far as Otherwise than Being) to show how the concept of the Totally Other addresses the most radical problem of justification for theological and philosophical thought.

Prompted and resolved by acts of volitional imagining, dramatizing figures a situation in which actors share in having something important at stake such that imminently some of their actions will be momentous (making great differences) and fateful (defining of lives). Religious dramatizing does this very ambitiously. In amplifying the stakes of action there is a danger of being inappropriately dramatic, as in Don Quixote’s fantasies or Chicken Little’s ‘The sky is falling!’ But dramatization can be validated by successfully enacting the (...) dramatic heightening of a situation, by conventionally instituting heights of importance, and by having convincing experiences of situations as dramatic. Kant worries about an inappropriately romantic dramatizing of the moral life; Lucretius warns that religious visionaries will make people crazy with fear of divine retribution. The issue is taken seriously within religious dramatizing. For example, apocalypticism seems to entail an irresponsible termination of care for continuing life. Correctives are offered by Hans Urs von Balthasar’s theory of ‘theo-drama’ and (Francis’s, 2015) encyclical ‘On Care for Our Common Home’. These examples show how the modulation of dramatizing is no less a religious concern than the dramatic heightening of human life. (shrink)

How might we think about relationships between philosophy as a way of life and the domain of the political? Or, since there are clearly, and importantly, multiple understandings of philosophy as a way of life and multiple aspects of the domain of the political, let me put my question somewhat more narrowly as: How might we think about relationships between the kind of ongoing work of self-cultivation and self-transformation which has been at least one continuing dimension of philosophy in the (...) West from its beginning and the existence, realities, and responsibilities of social life? (shrink)

Influential moral theories keyed to benevolence (including Mengzi’s and Hutcheson’s) claim a footing for ideal moral benevolence in natural human benevolence. The meaning of this claim depends on how natural and ideal benevolence are conceived and how the two are supposed to be related—as Mengzi suggests, for example, that there is an innate “sprout” of compassionate aversion to suffering that tends to grow into moral humaneness. In any case it is plausible that some sort of spontaneous and consistent human friendliness (...) supports a moral standard of unselfish concern for the well-being of others. The premise of benevolence theory is strengthened when we take account of a largely overlooked form of general good will: benevolent interest in the efforts of others. Here too a form of moral benevolence may grow from a base in natural good will, a point anticipated in Aristotle’s observation that our friendly interest in others is stimulated by the contestants in sports events. The sports spectator act of “pulling for” contestants, though conflicted by competition and exploited for various nonmoral satisfactions, is a vivid specimen of a general pulling for all innocent efforts in an inclusive moral fellowship of triers. (shrink)

If, as many historians and theorists now believe, narrative is the form proper to historical explanation, this raises the problem of the terms in which such narratives are to be evaluated. Without a clear account of evaluation, the status of historical knowledge remains obscure. Beginning with the view, found in Hayden White and others, that historical narrative constitutes a meaning not reducible to the factual content it engages, this essay argues that such meaning can arise only through a synthesis of (...) cognitive and normative discourses. Narrative combines "heterogeneous" language games in such a way that neither appeal to "truth content" nor to "justice" suffices to decide the question of which of two competing historical explanations is, as a whole, superior. Examining in critical detail the opposed positions on this issue articulated by two recent theorists-Frank Ankersmit and David Carr -the paper concludes that the debate between those who hold that historical narratives should be judged in essentially cognitive terms and those who hold that they should be judged in essentially political terms cannot be resolved and that a philosophical view of historical narrative that is neither realist nor idealist needs to be developed. (shrink)

I argue that Gold & Stoljar's “trivial neuron doctrine” is not in fact trivial. Many familiar positions in the philosophy of mind run afoul of it, and it is unclear that even those whom Gold & Stoljar identify as adherents of the trivial neuron doctrine can be comfortably described as such.

In numerous essays over the years, and most recently in his Meaning, Paul Horwich has worked to articulate and defend a version of the use theory of meaning. At the heart of his project is the idea that the meaning of a word is constituted by a regularity in speakers’ use of it — i.e., by a regularity in speakers’ dispositions to accept as true, to reject as false, or neither to accept nor to reject sentences containing it. A ‘use (...) regularity,’ thus construed, is a dispositional acceptance property distinctive of a particular word and, derivatively, of sentences containing the word. For example, the use regularity constituting the meaning of ‘red’ can be very roughly characterized as speakers’ disposition to accept the application of ‘red’ to observed surfaces if and only if they are clearly red. Of course, the use regularity constituting the meaning of a word can be described in different ways; in particular, in describing a use regularity we might merely mention, and not use, the corresponding word. Furthermore, not every regularity in the use of a word is meaning-constituting. The use regularity that constitutes the meaning of the word ‘tall,’ for example, does so in virtue of the fact that, taken together with general psychological laws and the use regularities governing other words, it is basic to the explanation of speakers’ overall pattern of use of ‘tall.’ Hence, a central claim of Horwich’s use theory is that linguistic use is in general to be ‘unified and explained in terms of a relatively small and simple body of factors and principles including, for each word, a basic use regularity’. (shrink)

The transactivation response‐DNA binding protein of 43 kDa (TDP‐43) is an aggregation‐prone nucleic acid‐binding protein linked to the etiology of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). These conditions feature the accumulation of insoluble TDP‐43 aggregates in the neuronal cytoplasm that lead to cell death. The dynamics between cytoplasmic and nuclear TDP‐43 are altered in the disease state where TDP‐43 mislocalizes to the cytoplasm, disrupting Nuclear Pore Complexes (NPCs), and ultimately forming large fibrils stabilized by the C‐terminal prion‐like (...) domain. Here, we review three emerging and poorly understood aspects of TDP‐43 biology linked to its aggregation. First, how post‐translational modifications in the proximity of TDP‐43 N‐terminal domain (NTD) promote aggregation. Second, how TDP‐43 engages FG‐nucleoporins in the NPC, disrupting the pore permeability and function. Third, how the importin α/β heterodimer prevents TDP‐43 aggregation, serving both as a nuclear import transporter and a cytoplasmic chaperone. (shrink)